Although the root cause of concern related to male infertility symptoms often remains a mystery, the research in regenerative medicine has displayed great potential in developing the treatment of infertility with stem cells by targeting the reasons for infertility. Today, 1 out of 8 couples in developed countries are facing issues in the treatment of male infertility. Moreover, about half of these issues are being attributed to semen abnormalities in the male partner. Earlier, things were not clear as to why penile erection fails to occur or what leads to reduced sperm mobility, etc. With extensive research, these challenges are now comprehensible to therapeutic ventures resulting in new treatments of male infertility using autologous transplant/allogeneic transplant for adipose-derived mesenchymal stromal cells treatment and bone marrow stromal cells treatment. This new insight on the treatment of male infertility has helped in identifying the potential to overcome infertility with stem cells, primarily using autologous stem cell transplant in form of hematopoietic stem cell transplant or
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